Distinct Lipid Transfer Proteins display different IgE‐binding activities that are affected by fatty acid binding
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چکیده
منابع مشابه
Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms.
Intestinal enterocytes contain high concentrations of two cytosolic fatty acid-binding proteins (FABP), liver FABP (L-FABP) and intestinal FABP (I-FABP), which are hypothesized to play a role in cellular fatty acid trafficking. The mechanism(s) by which fatty acids move from membranes to each of these proteins is not known. Here we demonstrate that fluorescent anthroyloxy fatty acid analogues (...
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A simple experimental system was developed for studying the movement of long-chain fatty acids between multilamellar liposomes and soluble proteins capable of binding fatty acids. Oleic acid was incorporated into multilamellar liposomes containing cholesterol and egg yolk lecithin and incubated with albumin or hepatic fatty acid-binding protein. It was found that the fatty acid transferred from...
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Although many growth factors and cytokines have been shown to be localized within the cell and nucleus, the mechanism by which these molecules elicit a biological response is not well understood. The cytokine leukemia inhibitory factor (LIF) provides a tractable experimental system to investigate this problem, because translation of alternatively spliced transcripts results in the production of...
متن کاملRegulation of fluorescent fatty acid transfer from adipocyte and heart fatty acid binding proteins by acceptor membrane lipid composition and structure.
Adipocyte and heart fatty acid binding proteins (A-FABP and H-FABP) are closely related members of the FABP family. Unlike the more distantly related liver FABP, these FABP have been proposed to transfer free fatty acids to model membranes by a collisional mechanism (Wootan, M. G., Bernlohr, D. A., and Storch, J. (1993) Biochemistry 32, 8622-8627; Kim, H. K., and Storch, J. (1992) J. Biol. Chem...
متن کاملFatty acid transport and fatty acid-binding proteins.
Les protkines de liaison ou de transfert des acides gras sont prCsentes dans les fluides intraet extra-cellulaires de la plupart des organismes. Elles jouent un r61e dans le transport ou le ciblage des acides gras, mais peuvent kgalement agir en interaction avec different processus par la modulation de la concentration de la liaison libre. Quelques protkines de liaison des acides gras sont asse...
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ژورنال
عنوان ژورنال: Allergy
سال: 2018
ISSN: 0105-4538,1398-9995
DOI: 10.1111/all.13682